Cisplatin
Cisplatin, a chemotherapy medication, has been instrumental in treating various types of cancer. This article aims to delve into the mechanism of action, potential side effects, and the diverse applications of cisplatin in modern medicine.
Mechanism of Action
Cisplatin exerts its anti-cancer effects by forming platinum-DNA adducts, leading to DNA damage and triggering apoptotic cell death in cancer cells. This mechanism disrupts the replication and transcription process, ultimately inhibiting tumor growth.
Impact of Gene Variants
Genetic variations can influence an individual‘s response to cisplatin therapy. Certain gene variants may affect the metabolism and clearance of cisplatin, thereby influencing its efficacy and the risk of adverse reactions.
