CIART
Description
The CIART (circadian associated repressor of transcription) is a protein-coding gene located on chromosome 1.
CIART, also known as ChIP-derived repressor of network oscillator or Computationally highlighted repressor of the network oscillator, is a transcriptional repressor that plays a crucial role in regulating the circadian clock. It acts independently of other known circadian repressors like CRY1, CRY2, and BHLHE41. CIART functions by suppressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer, a key component of the circadian clock. This suppression involves histone deacetylation, a process where CIART interacts with histone deacetylases to remove acetyl groups from histones, thereby reducing the accessibility of DNA to transcription factors. Additionally, CIART disrupts the interaction of BMAL1 with CREBBP, a transcriptional coactivator, further reducing the transcriptional activity of CLOCK-BMAL1. CIART binds rhythmically to E-box elements (5'-CACGTG-3') on circadian gene promoters, displaying a circadian oscillation pattern opposite to that of BMAL1. It also interacts with the glucocorticoid receptor (NR3C1), contributing to the repression of gene expression in response to glucocorticoids.
CIART is also known as C1orf51, CHRONO, GM129.
