CIAPIN1

Description

The CIAPIN1 (cytokine induced apoptosis inhibitor 1) is a protein-coding gene located on chromosome 16.

CIAPIN1 is a gene that encodes for the Anamorsin protein in humans. This protein is a cytokine-induced inhibitor of apoptosis that is unrelated to the apoptosis regulatory molecules of the BCL2 or CASP families. Its expression is triggered by growth factor stimulation.

CIAPIN1 is a crucial component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery, essential for the maturation of extramitochondrial Fe-S proteins. It participates in an electron transfer chain, playing a key role in the initial stages of cytosolic Fe-S biogenesis by facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are delivered to CIAPIN1 from NADPH through the FAD- and FMN-containing protein NDOR1. This NDOR1-CIAPIN1 complex is also necessary for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), likely by supplying electrons for reduction during radical cofactor maturation in the catalytic small subunit. CIAPIN1 exhibits anti-apoptotic effects within the cell, contributing to the negative control of cell death upon cytokine withdrawal. It promotes the development of hematopoietic cells.

CIAPIN1 is also known as Anamorsin, CIAE2, DRE2, PRO0915.

Associated Diseases

• type 2 diabetes mellitus
• hemoglobin E disease
• hemoglobin D disease
• dominant beta-thalassemia
• dehydrated hereditary stomatocytosis
• hemoglobin H disease
• hemolytic anemia due to diphosphoglycerate mutase deficiency
• cyanosis, transient neonatal
• hemoglobin C-beta-thalassemia syndrome
• hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome
• overhydrated hereditary stomatocytosis
• hemoglobin E-beta-thalassemia syndrome