CHST2
Description
The CHST2 (carbohydrate sulfotransferase 2) is a protein-coding gene located on chromosome 3.
Carbohydrate sulfotransferase 2 is an enzyme encoded by the CHST2 gene in humans. It is responsible for transferring sulfate groups to specific sugar residues, playing a crucial role in the formation of certain types of glycans.
CHST2 is a sulfotransferase that uses 3'-phospho-5'-adenylyl sulfate (PAPS) to attach sulfate groups to the 6th position of non-reducing N-acetylglucosamine (GlcNAc) residues. These GlcNAc residues are found within keratan-like structures on N-linked glycans and within mucin-associated glycans. These modified glycans act as ligands for SELL (L-selectin), which is expressed on high endothelial cells (HEVs) and plays a crucial role in lymphocyte homing to sites of inflammation. CHST2 is involved in the biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Notably, CHST2 does not act on O-linked sugars and its substrate specificity may be influenced by its subcellular location. It specifically targets GlcNAc residues at the terminal, non-reducing ends of oligosaccharide chains.
CHST2 is also known as C6ST, GST-2, GST2, Gn6ST-1, HEL-S-75, glcNAc6ST-1.
