CHST12

Description

The CHST12 (carbohydrate sulfotransferase 12) is a protein-coding gene located on chromosome 7.

The CHST12 gene encodes Carbohydrate sulfotransferase 12, an enzyme that plays a role in the sulfation of chondroitin and dermatan sulfate. These sulfated glycosaminoglycans are crucial components of cartilage and extracellular matrices.

CHST12 is also known as C4S-2, C4ST-2, C4ST2.

Associated Diseases

• multiple sclerosis
• Gollop-Wolfgang complex
• coxopodopatellar syndrome
• tibia, hypoplasia or aplasia of, with polydactyly
• fibular aplasia-ectrodactyly syndrome
• acromesomelic dysplasia 2C, Hunter-Thompson type
• Blount disease
• hip dysplasia, Beukes type
• metaphyseal anadysplasia
• familial clubfoot due to 17q23.1q23.2 microduplication
• acromesomelic dysplasia 2B
• mesomelic dysplasia, Savarirayan type