CHST10

Description

The CHST10 (carbohydrate sulfotransferase 10) is a protein-coding gene located on chromosome 2.

CHST10 is a human gene that encodes an enzyme called carbohydrate sulfotransferase 10. This enzyme is involved in the synthesis of HNK-1, a complex carbohydrate found on nerve cells. HNK-1 is essential for cell communication and development. The gene's location and details can be found on the UCSC Genome Browser.

CHST10 catalyzes the addition of a sulfate group to the third position of terminal glucuronic acid in both protein- and lipid-linked oligosaccharides. This process is crucial for the synthesis of HNK-1, a carbohydrate found on neural recognition molecules. HNK-1 plays a key role in cell interactions during development and in maintaining synaptic plasticity in the adult brain. CHST10 also contributes to the regulation of steroid hormones by sulfating glucuronidated estrogens and androgens, impacting hormone cycles and fertility.

CHST10 is also known as HNK-1ST, HNK1ST.

Associated Diseases

• Perrault syndrome
• premature ovarian failure 18
• premature ovarian failure 7
• double uterus-hemivagina-renal agenesis syndrome
• isolated congenital hypogonadotropic hypogonadism
• spermatogenic failure 15
• hypogonadotropic hypogonadism
• 46,XY complete gonadal dysgenesis
• 46,XX ovotesticular disorder of sex development
• mullerian aplasia and hyperandrogenism
• partial androgen insensitivity syndrome
• complete androgen insensitivity syndrome