CHRAC1

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Description

The CHRAC1 (chromatin accessibility complex subunit 1) is a protein-coding gene located on chromosome 8.

CHRAC1 forms a complex with POLE3 and binds to naked DNA. This DNA is then incorporated into chromatin with the help of ISWI/SNF2H and ACF1, which remodel nucleosomes. However, CHRAC1 does not enhance the nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.

CHRAC1 is also known as CHARC1, CHARC15, CHRAC-1, CHRAC-15, CHRAC15, YCL1.

Associated Diseases

• cancer
• thrombocytopenia 4
• macrothrombocytopenia, isolated, 2, autosomal dominant
• autosomal dominant macrothrombocytopenia
• beta-thalassemia-X-linked thrombocytopenia syndrome
• platelet-type bleeding disorder 10
• platelet-type bleeding disorder 15
• thrombocytopenia 2
• platelet-type bleeding disorder 9
• thrombocytopenia 7