CHRAC1
Description
The CHRAC1 (chromatin accessibility complex subunit 1) is a protein-coding gene located on chromosome 8.
CHRAC1 forms a complex with POLE3 and binds to naked DNA. This DNA is then incorporated into chromatin with the help of ISWI/SNF2H and ACF1, which remodel nucleosomes. However, CHRAC1 does not enhance the nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.
CHRAC1 is also known as CHARC1, CHARC15, CHRAC-1, CHRAC-15, CHRAC15, YCL1.
Associated Diseases
- cancer
- thrombocytopenia 4
- macrothrombocytopenia, isolated, 2, autosomal dominant
- autosomal dominant macrothrombocytopenia
- beta-thalassemia-X-linked thrombocytopenia syndrome
- platelet-type bleeding disorder 10
- platelet-type bleeding disorder 15
- thrombocytopenia 2
- platelet-type bleeding disorder 9
- thrombocytopenia 7
