CHP2
Description
The CHP2 (calcineurin like EF-hand protein 2) is a protein-coding gene located on chromosome 16.
CHP2, also known as Hepatocellular carcinoma-associated antigen 520, is a protein that plays a vital role in regulating cell pH, proliferation, and tumor growth. It is an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. CHP2 binds to and activates SLC9A1/NHE1, increasing pH and protecting cells from serum deprivation-induced death. It also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. CHP2 is an activator of the calcineurin/NFAT signaling pathway and is involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
CHP2 acts as a crucial cofactor in maintaining the pH balance within cells by regulating the exchange of sodium and hydrogen ions across the cell membrane. It directly interacts with and activates SLC9A1/NHE1, a protein responsible for this exchange, independent of serum levels. This activation leads to an increase in cellular pH, safeguarding cells from death caused by the absence of serum. CHP2 further contributes to cell growth and tumor development by enhancing the activity of PPP3CA, a phosphatase, in a calcium-dependent manner. CHP2 is also known to be an activator of the calcineurin/NFAT signaling pathway, facilitating the movement of the NFATC3 transcription factor from the cytoplasm into the nucleus.
CHP2 is also known as -.
