CHMP7
Description
The CHMP7 (charged multivesicular body protein 7) is a protein-coding gene located on chromosome 8.
CHMP7 is an ESCRT-III-like protein that is crucial for recruiting the ESCRT-III complex to the nuclear envelope (NE) during late anaphase. This recruitment is essential for proper NE sealing and mitotic spindle disassembly during late anaphase. CHMP7 works in conjunction with SPAST to facilitate these processes. LEMD2 is responsible for recruiting CHMP7 to the reforming NE during anaphase. CHMP7 also plays a role in the endosomal sorting pathway.
CHMP7 is also known as -.
Associated Diseases
- COVID-19
- uncombable hair syndrome
- Griscelli syndrome type 3
- pili bifurcati
- oculocutaneous albinism type 3
