CHMP5
Description
The CHMP5 (charged multivesicular body protein 5) is a protein-coding gene located on chromosome 9.
Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene. CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.
CHMP5, also known as Chromatin-modifying protein 5, is a protein involved in the formation of multivesicular bodies (MVBs) and sorting of endosomal cargo proteins into MVBs. It is a component of the ESCRT-III complex, which is involved in the invagination and scission of the limiting membrane of the endosome, generating intraluminal vesicles (ILVs). These ILVs are delivered to lysosomes for degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. CHMP5 interacts with other ESCRT-III components like VTA1, CHMP2A and NOD2 and may play a role in the assembly and function of ESCRT-III complexes. It is believed to be involved in vesicle extrusion and/or membrane fission activities during MVB formation, potentially working in conjunction with the AAA ATPase VPS4. CHMP5 also plays a role in the budding of enveloped viruses, including HIV-1, and is involved in HIV-1 p6- and p9-dependent virus release.
CHMP5 is also known as C9orf83, CGI-34, HSPC177, PNAS-2, SNF7DC2, Vps60.
