CHML
Chronic Myeloid Leukemia (CML): A Comprehensive Guide
Chronic myeloid leukemia (CML) is a type of cancer that affects the blood and bone marrow. It is characterized by the overproduction of white blood cells, specifically neutrophils and eosinophils. CML is a chronic disease, meaning that it can last for a long time. However, with treatment, most people with CML can live a normal life.
Description
CML occurs when a specific genetic mutation, known as the Philadelphia chromosome, develops in bone marrow cells. This mutation leads to the formation of a fusion protein called BCR-ABL1, which causes the overproduction of white blood cells. The abnormal white blood cells can crowd out healthy blood cells, leading to symptoms such as fatigue, weakness, and an increased risk of infection.
Associated Diseases
CML is often associated with other conditions, including:
- Myelofibrosis: A condition that causes scarring of the bone marrow, leading to a decrease in blood production.
- Polycythemia vera: A condition that causes an increase in the production of red blood cells.
- Essential thrombocythemia: A condition that causes an increase in the production of platelets.
Did you Know ?
According to the American Cancer Society, approximately 8,000 people in the United States are diagnosed with CML each year. The average age at diagnosis is 65 years old.
Treatment
Treatment for CML typically involves medication to target the BCR-ABL1 fusion protein. These medications, known as tyrosine kinase inhibitors (TKIs), have significantly improved the prognosis for people with CML. With TKIs, most people can achieve a complete remission, meaning that the disease is undetectable.
