CHIA

Description

The CHIA (chitinase acidic) is a protein-coding gene located on chromosome 1.

CHIA (Acidic mammalian chitinase) breaks down chitin and chitotriose, which are components of fungal and nematode cell walls. This activity may help defend against these pathogens. CHIA also plays a role in the T-helper cell type 2 (Th2) immune response, contributing to inflammation triggered by IL-13. It stimulates chemokine production in lung epithelial cells, protects them from apoptosis, and promotes AKT1 phosphorylation. The inhibitor allosamidin blocks CHIA's inflammatory and anti-apoptotic actions, indicating that its function relies on carbohydrate binding.

CHIA is also known as AMCASE, CHIT2, TSA1902.

Associated Diseases

• neutrophil immunodeficiency syndrome
• X-linked severe congenital neutropenia
• transient myeloproliferative syndrome
• neutropenia, severe congenital, 2, autosomal dominant
• neutropenia, severe congenital, 1, autosomal dominant
• combined immunodeficiency due to moesin deficiency
• agammaglobulinemia 7, autosomal recessive
• nonimmune chronic idiopathic neutropenia of adults
• autosomal recessive severe congenital neutropenia due to CSF3R deficiency
• X-linked sideroblastic anemia 1
• immunodeficiency 67