CHD3 : chromodomain helicase DNA binding protein 3
Description
The CHD3 (chromodomain helicase DNA binding protein 3) is a protein-coding gene located on chromosome 17.
The CHD3 gene provides instructions for making a protein that regulates gene activity (expression) by a process known as chromatin remodeling. Chromatin is the complex of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. When DNA is tightly packed, gene expression is lower than when DNA is loosely packed. Chromatin remodeling is one way gene expression is regulated during development. The CHD3 protein helps with chromatin remodeling by moving components called nucleosomes, that help bundle DNA in a tight package. Moving nucleosomes helps make DNA more accessible for gene expression. The CHD3 protein provides energy for this remodeling by breaking down a molecule called ATP. Through its ability to regulate gene activity, the CHD3 protein is involved in many processes during development, including maintenance of the structure and integrity of DNA, the maturation process that determines the type of cell an immature cell will ultimately become (cell fate determination), and the growth of cells as they progress through the step-by-step process they take to replicate themselves (the cell cycle).
CHD3 is an ATP-dependent helicase that binds and distorts nucleosomal DNA. It is a component of the NuRD complex, which is involved in chromatin remodeling and transcriptional repression. CHD3 is required for anchoring centrosomal pericentrin during interphase and mitosis, playing a role in spindle organization and centrosome integrity.
CHD3 is also known as Mi-2a, Mi2-ALPHA, SNIBCPS, ZFH.
