CHAMP1
Description
The CHAMP1 (chromosome alignment maintaining phosphoprotein 1) is a protein-coding gene located on chromosome 13.
CHAMP1, also known as zinc finger protein 828 (ZNF828), is a protein encoded by the CHAMP1 gene in humans. It is crucial for the proper alignment of chromosomes during metaphase and their accurate segregation during mitosis. CHAMP1 is involved in maintaining the connection between spindle microtubules and the kinetochore, ensuring accurate sister chromatid biorientation. It may also help recruit CENPE and CENPF to the kinetochore. CHAMP1 interacts with several other proteins involved in chromosome segregation, including MAD2L2, POGZ, CBX1, CBX3, and CBX5. There are dedicated charities and research foundations focused on CHAMP1 disorders. Information about the CHAMP1 gene and its location on the human genome can be found on the UCSC Genome Browser.
CHAMP1 plays a crucial role in ensuring proper chromosome alignment during cell division (mitosis). It helps maintain the connection between spindle microtubules and the kinetochore, the structure that attaches to chromosomes. This connection is essential for the accurate separation of sister chromatids during mitosis. CHAMP1 might also help recruit CENPE and CENPF, two proteins involved in chromosome segregation, to the kinetochore.
CHAMP1 is also known as C13orf8, CAMP, CHAMP, MRD40, NEDHILD, ZNF828.
