CHAF1B
Description
The CHAF1B (chromatin assembly factor 1 subunit B) is a protein-coding gene located on chromosome 21.
CHAF1B is a gene that encodes the p60 subunit of Chromatin assembly factor I (CAF-1), a crucial protein complex involved in assembling histone octamers onto newly replicated DNA. This protein is essential for chromatin assembly following replication and undergoes phosphorylation in a cell cycle-dependent manner. Typically located in the nucleus, CHAF1B is released into the cytoplasm during mitosis. It belongs to the WD-repeat HIR1 family and may also play a role in DNA repair. CHAF1B interacts with ASF1A, ASF1B, and BAZ1B.
The CHAF1B protein is part of the Chromatin Assembly Factor 1 (CAF-1) complex. This complex plays a critical role in DNA replication and repair by assembling histone octamers onto newly replicated DNA. Specifically, CAF-1 initiates the nucleosome assembly process by delivering newly synthesized histone H3 and H4 to replicating DNA. Subsequently, histones H2A/H2B bind to this chromatin precursor, completing the histone octamer formation.
CHAF1B is also known as CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7.
