CHAF1A
Description
The CHAF1A (chromatin assembly factor 1 subunit A) is a protein-coding gene located on chromosome 19.
Chromatin assembly factor 1 subunit A (CHAF1A) is a protein encoded by the CHAF1A gene in humans. It is a subunit of the Chromatin assembly factor I (CAF-1) complex, a nuclear complex consisting of p50, p60 (CHAF1B), and p150 (CHAF1A) subunits. CAF-1 assembles histone tetramers onto replicating DNA in vitro. CHAF1A interacts with ASF1A, ASF1B, BLM, CBX5, and MBD1.
CHAF1A is a core component of the CAF-1 complex, which plays a crucial role in chromatin assembly during DNA replication and repair. This complex facilitates the assembly of histone octamers onto newly synthesized DNA. Specifically, CAF-1 initiates the nucleosome assembly process by bringing newly synthesized histone H3 and H4 to the replicating DNA. Subsequently, histones H2A/H2B bind to this chromatin precursor after DNA replication, completing the histone octamer. Additionally, CHAF1A may contribute to the maintenance of heterochromatin in proliferating cells by delivering newly synthesized CBX proteins to heterochromatic DNA replication foci.
CHAF1A is also known as CAF-1, CAF1, CAF1B, CAF1P150, P150.
