CHAD

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Description

The CHAD (chondroadherin) is a protein-coding gene located on chromosome 17.

CHAD promotes the binding of chondrocytes, fibroblasts, and osteoblasts to the extracellular matrix. This attachment, at least for chondrocytes and fibroblasts, is facilitated by the integrin alpha(2)beta(1). CHAD is thought to be involved in regulating the growth and proliferation of chondrocytes.

CHAD is also known as SLRR4A.

Associated Diseases

• melorheostosis with osteopoikilosis
• hyperostosis corticalis generalisata
• gnathodiaphyseal dysplasia
• Eiken syndrome
• hip dysplasia, Beukes type
• autosomal dominant osteosclerosis, Worth type
• autosomal recessive osteopetrosis 6
• Caffey disease
• metaphyseal dysplasia, Braun-Tinschert type
• ghosal hematodiaphyseal dysplasia
• osteogenesis imperfecta, IIA 22
• osteosclerotic metaphyseal dysplasia
• sclerosteosis
• wormian bone-multiple fractures-dentinogenesis imperfecta-skeletal dysplasia
• familial expansile osteolysis
• hereditary sensory and autonomic neuropathy type 2
• dentin dysplasia-sclerotic bones syndrome