CHAC1
Description
The CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1) is a protein-coding gene located on chromosome 15.
CHAC1, also known as Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1), specifically cleaves glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. It does not act on other gamma-glutamyl peptides. Depletion of glutathione is crucial for initiating and executing apoptosis. CHAC1 acts as a pro-apoptotic component within the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Furthermore, CHAC1 acts as a negative regulator of the Notch signaling pathway involved in embryonic neurogenesis. It inhibits Notch cleavage by furin, keeping Notch in an immature, inactive form, thereby promoting neurogenesis in embryos.
CHAC1 is also known as -.
