CGB5
CGB5: A Comprehensive Guide
Description:
CGB5 (chorionic gonadotropin beta-5 subunit) is a protein hormone secreted by the placenta during pregnancy. It is a glycoprotein composed of 145 amino acids and plays a crucial role in maintaining pregnancy by supporting the growth and development of the fetus. CGB5 levels rise rapidly during the first trimester, peaking around the 10th to 12th week of gestation. They then gradually decline as the pregnancy progresses.
Associated Diseases:
Abnormal CGB5 levels can be associated with various pregnancy complications, including:
- Gestational Trophoblastic Disease (GTD): Characterized by abnormal growth or development of the placenta, GTD includes conditions such as hydatidiform mole and choriocarcinoma. Elevated CGB5 levels can be an indicator of GTD.
- Ectopic Pregnancy: A condition in which the fertilized egg implants outside the uterus, often in the fallopian tube. Low levels of CGB5 in the blood may be suggestive of an ectopic pregnancy.
- Fetal Abnormalities: In cases where the fetus has certain chromosomal or genetic abnormalities, such as Down Syndrome or Trisomy 18, maternal CGB5 levels may be altered.
Did you Know ?
According to a 2018 study published in the journal "Prenatal Diagnosis," elevated CGB5 levels in the first trimester are associated with an increased risk of preeclampsia (a pregnancy-related complication characterized by high blood pressure and protein in the urine). The study found that women with CGB5 levels in the top 25% had a 3.5-fold increased risk of developing preeclampsia compared to those with CGB5 levels in the bottom 25%.
