CGA

Description

The CGA (glycoprotein hormones, alpha polypeptide) is a protein-coding gene located on chromosome 6.

CGA is a human gene that encodes a glycoprotein hormone alpha chain. It is involved in the production of several important hormones, including thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG). These hormones play crucial roles in regulating various bodily functions, such as growth, development, and reproduction.

CGA is the shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin (TSH), lutropin (LH), follitropin (FSH), and choriogonadotropin (CG). These hormones bind to specific receptors on target cells, which activate downstream signaling pathways.

CGA is also known as CG-ALPHA, FSHA, GPA1, GPHA1, GPHa, HCG, LHA, TSHA.

Associated Diseases

• Alzheimer disease
• Parkinson disease
• multiple sclerosis
• lysosomal storage disease
• ovarian cancer
• endometrial cancer
• Kallmann syndrome
• isolated congenital hypogonadotropic hypogonadism
• 46,XY partial gonadal dysgenesis