CFL1
Description
The CFL1 (cofilin 1) is a protein-coding gene located on chromosome 11.
Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.
== Interactions == Cofilin 1 has been shown to interact with HSPH1 and LIMK1.
CFL1 binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. It plays an essential role in the progression of zygotes beyond the first embryonic cell divisions by regulating actin dynamics. CFL1 is required for the centralization of the mitotic spindle and symmetric division of zygotes. It plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells. CFL1 is required for the up-regulation of atypical chemokine receptor ACKR2 from the endosomal compartment to the cell membrane, increasing its efficiency in chemokine uptake and degradation. It is required for neural tube morphogenesis and neural crest cell migration.
CFL1 is also known as CFL, HEL-S-15, cofilin.
