CETN3
Description
The CETN3 (centrin 3) is a protein-coding gene located on chromosome 5.
Centrin-3 is a protein encoded by the CETN3 gene in humans. It belongs to the centrin family of proteins, which are characterized by having four EF-hand calcium binding domains. These proteins are evolutionarily conserved and resemble the CDC31 protein found in yeast. In yeast, CDC31 is located at the centrosome, a crucial structure for cell division, where it plays a vital role in centrosome duplication and separation. Multiple forms of centrin proteins have been identified in humans and other mammals, some of which have been shown to be associated with centrosomes. Centrin-3 appears to be one of the most abundant centrins at the centrosome, suggesting a similar function to its yeast counterpart.
CETN3 plays a crucial role in maintaining the structure and function of the microtubule-organizing center, a key component in cell division and organization.
CETN3 is also known as CDC31, CEN3.
