CETN2
Description
The CETN2 (centrin 2) is a protein-coding gene located on chromosome X.
Centrin-2 is a protein encoded by the CETN2 gene in humans. It belongs to the centrin family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggest that centrin-2 plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. CETN2 has been shown to interact with XPC and SFI1.
CETN2, also known as Caltractin isoform 1, plays a crucial role in the structure and function of the microtubule organizing center (MTOC). It is essential for centriole duplication and the formation of a correctly oriented spindle during cell division. CETN2 contributes to the regulation of cytokinesis (cell division) and genome stability by collaborating with CALM1 and CCP110.
CETN2 is also known as CALT, CEN2.
Associated Diseases
- endometrial cancer
- esophageal cancer
- breast cancer
- major depressive disorder
- lung neoplasm
- intrahepatic bile duct cancer
- colorectal cancer
