CEP72
Description
The CEP72 (centrosomal protein 72) is a protein-coding gene located on chromosome 5.
CEP72, also known as Centrosomal protein of 72 kDa, is a protein encoded by the CEP72 gene in humans. It belongs to the Leucine-rich repeat (LRR) superfamily of proteins and is located at the centrosome, a non-membraneous organelle that serves as the primary microtubule-organizing center in animal cells.
CEP72 plays a crucial role in the recruitment of essential centrosomal proteins to the centrosome, thereby contributing to its proper function. It facilitates microtubule nucleation at the gamma-tubulin ring complexes (gamma-TuRCs), which is essential for the formation of a focused bipolar spindle. This spindle is vital for generating the necessary tension between sister chromatids during cell division. CEP72 is also involved in the localization of key proteins like KIZ, AKAP9, and gamma-TuRCs, ensuring their proper distribution at the centrosome. Additionally, CEP72 participates in centriole duplication, a critical process for cell division. This protein is required for the correct localization of other centrosomal proteins, including CDK5RAP22, CEP152, WDR62, and CEP63, and promotes the centrosomal accumulation of CDK2.
CEP72 is also known as -.
Associated Diseases
- ovarian cancer
- peptic ulcer disease
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 20
- spermatogenic failure 72
- spermatogenic failure 46
