CENPBD1
CENPB: An Essential Protein for Cell Division and Genome Stability
Description:
CENPB (centromere protein B) is a vital protein involved in several fundamental cellular processes, including cell division and genome stability. It plays a key role in kinetochore assembly, which is the complex structure that connects chromosomes to spindle fibers during cell division. CENPB ensures the proper attachment of chromosomes to spindle fibers, facilitating the accurate separation and distribution of genetic material to daughter cells.
Associated Diseases:
Mutations in the CENPB gene have been linked to several diseases, including:
- Aneuploidy: A condition where cells have an abnormal number of chromosomes, often due to errors in chromosome segregation during cell division.
- Miscarriage: CENPB mutations can disrupt chromosome segregation during early embryonic development, leading to miscarriage.
- Cancer: Altered CENPB expression or function has been associated with increased incidence and progression of certain types of cancer, such as breast and lung cancer.
Did you Know ?
In individuals with Down syndrome, a genetic disorder caused by an extra copy of chromosome 21, CENPB overexpression has been observed. This suggests a possible role of CENPB dysregulation in the pathogenesis of Down syndrome.
