CEMIP
Description
The CEMIP (cell migration inducing hyaluronidase 1) is a protein-coding gene located on chromosome 15.
CEMIP (Cell migration-inducing and hyaluronan-binding protein), previously known as KIAA1199, is a protein encoded by the CEMIP gene in humans. CEMIP binds to hyaluronic acid and breaks it down without the help of other proteins like CD44 or hyaluronidases. This function has been observed in both humans and mice. CEMIP has been linked to nonsyndromic deafness and various types of cancer.
CEMIP mediates the breakdown of hyaluronic acid (HA) through a process called endocytosis, where the cell membrane engulfs HA and forms small vesicles. CEMIP binds to HA and breaks down large HA molecules into smaller pieces. This process happens quickly and involves recycling the vesicles without storing or digesting the HA within the cell. CEMIP plays a role in breaking down HA in the skin and in the joints of people with arthritis. It also promotes the transformation of epithelial cells into mesenchymal cells, which contributes to tumor growth, invasion, and spread. Working together with the protein HSPA5/BIP, CEMIP helps cancer cells move around, a process that depends on calcium and PKC signaling.
CEMIP is also known as CCSP1, CEMIP1, HYBID, KIAA1199, TMEM2L.
