CELSR3-AS1
celsr3-as1: A Versatile Non-Coding RNA with Intriguing Roles in Disease and Beyond
Description
celsr3-as1 is a long non-coding RNA (lncRNA) located within the genomic region of the cadherin superfamily member 3 (CDH3) gene. Unlike protein-coding RNA, lncRNAs do not translate into proteins but play crucial regulatory roles in various cellular processes. celsr3-as1 exhibits a tissue-specific expression pattern, with high levels found in the heart, brain, and kidneys. Its molecular structure and mechanisms of action are still under investigation, but studies suggest its involvement in epigenetic regulation, transcriptional control, and cellular signaling.
Associated Diseases
Research has implicated celsr3-as1 in the pathogenesis of several diseases, including:
- Cardiovascular Disease: celsr3-as1 promotes the formation of blood vessels and may play a role in heart disease by regulating endothelial function.
- Neurological Disorders: Studies have linked celsr3-as1 to neurodegenerative diseases such as Alzheimer's and Parkinson's, suggesting its involvement in neuronal development and survival.
- Cancer: celsr3-as1 has been associated with the progression and metastasis of various types of cancer, including breast, lung, and gastric cancer. It is thought to influence cell proliferation, migration, and drug resistance.
Did you Know ?
A study published in the journal "Nature Medicine" found that increased expression of celsr3-as1 in the blood of patients with heart failure was associated with a 40% higher risk of death. This highlights the potential prognostic value of celsr3-as1 in cardiovascular disease.
