CELF5
Description
The CELF5 (CUGBP Elav-like family member 5) is a protein-coding gene located on chromosome 19.
CELF5 is a crucial RNA-binding protein involved in controlling the alternative splicing of pre-messenger RNA (pre-mRNA). It acts as a switch, either promoting or preventing the inclusion of specific exons within the pre-mRNA molecule. This process is highly regulated, influenced by the type of tissue and the developmental stage of the organism. Notably, CELF5 plays a key role in the development of the heart by promoting the inclusion of exon 5 in the TNNT2 gene, which is crucial for producing specific cardiac isoforms of the troponin T protein. This activation happens during the transition from a young to an adult heart, a period of significant heart remodeling. CELF5 achieves this by binding to specific regions called muscle-specific splicing enhancers (MSEs) located within the introns flanking exon 5 of the TNNT2 gene.
CELF5 is also known as BRUNOL-5, BRUNOL5, CELF-5.
