CELA1
Description
The CELA1 (chymotrypsin like elastase 1) is a protein-coding gene located on chromosome 12.
CELA1, also known as Elastase-1 (ELA1), is an enzyme encoded by the CELA1 gene in humans. It belongs to the elastase family of serine proteases, which break down various proteins, including elastin. While it was previously thought to be expressed in the pancreas and referred to as pancreatic elastase 1, it has been found to be expressed only in skin keratinocytes. This enzyme has been linked to chronic pancreatitis. Unlike other elastases, CELA1 is not expressed in the pancreas. Other elastases in humans include elastase 2, 2A, 2B, 3A, and 3B.
CELA1 is a serine protease that breaks down various proteins, including elastin.
CELA1 is also known as ELA1.
Associated Diseases
- keratoconus
- familial primary pulmonary hypoplasia
- congenital lobar emphysema
- hyperinsulinemic hypoglycemia, familial, 4
- autoimmune pancreatitis
