CECR6
cecr6
Description:
Cecr6, also known as C-C chemokine receptor type 6, is a G protein-coupled receptor (GPCR) that plays a crucial role in immune responses. It is primarily expressed on the surface of natural killer (NK) cells, monocytes, and dendritic cells. Cecr6 binds to several chemokines, including CCL20, CCL25, and CCL28, which regulate cell migration and activation.
Associated Diseases:
Dysregulation of Cecr6 signaling has been implicated in various autoimmune and inflammatory diseases, including:
- Multiple sclerosis (MS): Cecr6 is upregulated on activated CD4+ T cells in MS patients, contributing to Th17 cell differentiation and inflammatory responses.
- Rheumatoid arthritis (RA): Cecr6 expression is increased in synovial tissues of RA patients, promoting synovial inflammation and joint destruction.
- Inflammatory bowel disease (IBD): Cecr6 deficiency in mice has been shown to protect against experimental colitis, suggesting its role in IBD pathogenesis.
- Atopic dermatitis (AD): Cecr6 expression is elevated in lesional skin of AD patients, contributing to eosinophil recruitment and allergic inflammation.
- Cancer: Cecr6 is expressed on various tumor cells and is involved in tumor growth, metastasis, and angiogenesis.
Did you Know ?
According to a study published in the journal "Immunity," Cecr6 deficiency in mice resulted in a significant reduction in the development of experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
