CECR5
CCR5: A Critical Receptor in Immunology and Disease
Description:
CCR5, short for C-C chemokine receptor type 5, is a protein receptor expressed on the surface of certain immune cells, primarily monocytes, macrophages, and T cells. It plays a crucial role in the immune response, particularly in the recruitment and activation of these cells to sites of infection or inflammation.
Associated Diseases:
CCR5 has been linked to several diseases, including:
- HIV-1 Infection: CCR5 is one of the main co-receptors used by HIV-1 to enter immune cells, making individuals with certain CCR5 variants more susceptible to infection.
- AIDS: CCR5 mutations that prevent HIV-1 entry confer resistance to developing AIDS.
- West Nile Virus Infection: CCR5 facilitates the entry of West Nile virus into macrophages, contributing to severe neurological symptoms in some cases.
- Inflammatory Diseases: Dysregulation of CCR5 signaling has been implicated in various inflammatory conditions, such as rheumatoid arthritis, multiple sclerosis, and asthma.
Did you Know ?
- A naturally occurring CCR5 mutation known as CCR5-Δ32 is present in approximately 10% of the Caucasian population. This mutation results in a non-functional CCR5 receptor, providing an inherent resistance to HIV-1 infection.
