CEBPD
Description
The CEBPD (CCAAT enhancer binding protein delta) is a protein-coding gene located on chromosome 8.
CEBPD, also known as CCAAT/enhancer-binding protein delta, is a protein encoded by the CEBPD gene. It functions as a bZIP transcription factor, binding to specific DNA regulatory regions as a homodimer or heterodimer with CEBP-alpha. CEBPD plays a vital role in regulating genes involved in immune and inflammatory responses, and may contribute to the regulation of genes associated with macrophage activation and/or differentiation. CEBPD is involved in the regulation of apoptosis and cell proliferation and is likely a tumor suppressor. Studies in mice have shown that CEBPD prevents the development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy. The function of the CEBPD gene can be effectively examined using siRNA knockdown, which has been independently validated. CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.
CEBPD, also known as CCAAT/enhancer-binding protein delta (C/EBP delta) or Nuclear factor NF-IL6-beta, is a transcription activator. It recognizes two distinct DNA motifs: the CCAAT homology present in many promoters and the enhanced core homology found in many enhancers. CEBPD plays a crucial role in regulating the expression of genes involved in immune and inflammatory responses. It enhances IL6 transcription both independently and as a heterodimer with CEBPB.
CEBPD is also known as C/EBP-delta, CELF, CRP3, NF-IL6-beta.
