CEACAM5

Description

The CEACAM5 (CEA cell adhesion molecule 5) is a protein-coding gene located on chromosome 19.

CEACAM5, also known as CD66e, is a member of the carcinoembryonic antigen (CEA) gene family. Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells. It also plays a significant role in the inhibition of differentiation and apoptosis in colon cells. High CEACAM5 expression is associated with CD133-positive colorectal cancer stem cells and is found in about 25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC). CEACAM5 is often used as a synonym for CEA, a well-known biomarker for many types of malignancies, including colorectal cancer and non-small-cell lung cancer.

CEACAM5 is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling, and tumor progression. It mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. CEACAM5 acts as an oncogene by promoting tumor progression and inducing resistance to anoikis of colorectal carcinoma cells.

CEACAM5 is also known as CD66e, CEA.

Associated Diseases


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