CEACAM4
Description
The CEACAM4 (CEA cell adhesion molecule 4) is a protein-coding gene located on chromosome 19.
CEACAM4 is a gene that encodes carcinoembryonic antigen. It is predicted to be involved in phagocytosis and to act upstream of or within flagellated sperm motility. It is located in the extracellular region and shares similarities with other human genes including CEACAM4. It interacts with 1-naphthyl isothiocyanate, 17alpha-ethynylestradiol, and 2,3,4,7,8-Pentachlorodibenzofuran.
CEACAM4 functions as a receptor that initiates efficient phagocytosis of bound particles.
CEACAM4 is also known as CGM7, CGM7_HUMAN, NCA.
Associated Diseases
- hyperinsulinism due to INSR deficiency
- hyperinsulinism due to glucokinase deficiency
- exercise-induced hyperinsulinism
- nonpapillary renal cell carcinoma
- cholesterol-ester transfer protein deficiency
- hypertriglyceridemia 2
- glycogen storage disorder due to hepatic glycogen synthase deficiency
- hyperinsulinemic hypoglycemia, familial, 4
- hyperinsulinemic hypoglycemia, familial, 1
- hyperinsulinemic hypoglycemia, familial, 2
- islet cell adenomatosis
- pancreatic triacylglycerol lipase deficiency
- hyperinsulinism-hyperammonemia syndrome
- diabetes mellitus, permanent neonatal 4
- homozygous familial hypercholesterolemia
- diabetes mellitus, transient neonatal, 3
- transient neonatal diabetes mellitus
- sitosterolemia
