CDX1
Description
The CDX1 (caudal type homeobox 1) is a protein-coding gene located on chromosome 5.
CDX1 is a homeobox transcription factor expressed in the developing endoderm and persists in the adult intestine. Its expression varies along the intestine, being high in intestinal crypts and diminishing along villi. CDX1 regulates intestine-specific gene expression and enterocyte differentiation. It induces expression of the intestinal alkaline phosphatase gene and inhibits beta-catenin/T-cell factor transcriptional activity. CDX1 also plays a role in embryonic epicardial development by suppressing cardiac differentiation in zebrafish and mouse embryonic stem cells. Transient expression of CDX1 in the embryonic heart at 11.5 days post coitum is thought to induce epicardial epithelial-to-mesenchymal transition, contributing to proper cardiovascular formation.
CDX1 is also known as -.
Associated Diseases
- anorectal malformation
- colorectal cancer
- autosomal recessive spondylocostal dysostosis
- autosomal dominant spondylocostal dysostosis
- posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome
- Scheuermann disease
- brachyolmia, Maroteaux type
- autosomal dominant brachyolmia
- Klippel-Feil syndrome 3, autosomal dominant
- Prata-Liberal-Goncalves syndrome
- Becker nevus syndrome
- osteomesopyknosis
- spondylometaphyseal dysplasia, A4 type
- spondylocamptodactyly syndrome
- spondyloepiphyseal dysplasia tarda, Kohn type
- thoracolaryngopelvic dysplasia
- primary basilar invagination
