CDKN2B-AS1
Description
The CDKN2B-AS1 (CDKN2B antisense RNA 1) is a ncRNA gene located on chromosome 9.
CDKN2B-AS, also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 exons, spanning 126.3kb in the genome, and its spliced product is a 3834bp RNA. It is located within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the antisense direction. Single nucleotide polymorphisms (SNPs) which alter the expression of CDKN2B-AS are associated with human healthy life expectancy, as well as with multiple diseases, including coronary artery disease, diabetes and many cancers. It binds to chromobox 7 (CBX7) within the polycomb repressive complex 1 and to SUZ12, a component of polycomb repression complex 2 and through these interactions is involved in transcriptional repression.
CDKN2B-AS1, also known as ANRIL (antisense non-coding RNA in the INK4 locus), is a long non-coding RNA involved in transcriptional repression. It interacts with proteins like CBX7 (within the polycomb repressive complex 1) and SUZ12 (a component of polycomb repression complex 2), potentially influencing gene expression. This RNA is linked to human longevity and various health conditions, including coronary artery disease, diabetes, and multiple cancers. Genetic variations within CDKN2B-AS1 can impact its expression levels, contributing to these associations.
CDKN2B-AS1 is also known as ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS.
