CDKAL1
Description
The CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1) is a protein-coding gene located on chromosome 6.
CDKAL1 (Cdk5 regulatory associated protein 1-like 1) is a gene belonging to the methylthiotransferase family. Its precise physiological role and implications are not fully understood. CDKAL1 encodes CDK5 regulatory subunit-associated protein 1, which is found in various tissues, including neuronal tissues and pancreatic beta cells. CDKAL1 is believed to be involved in the CDK5/p35 pathway, where p35 activates CDK5, regulating various neuronal functions.
Structure and function Structurally, CDKAL1 contains two iron-sulfur (Fe-S) clusters, making it susceptible to inhibition by disrupting Fe-S cluster biosynthesis. Enzymatically, CDKAL1 catalyzes the methylthiolation of N6-threonylcarbamoyl adenosine 37 (t6A37) in cytosolic tRNA, stabilizing anticodon-codon interactions during translation.
Clinical significance In humans, CDKAL1 is implicated in type II diabetes. Mutations in CDKAL1 and TCF7L2 are associated with decreased insulin production. Studies suggest that CDKAL1 variants modify tRNA, increasing the risk of type II diabetes and obesity.
CDKAL1 is also known as -.
