CDK16

Description

The CDK16 (cyclin dependent kinase 16) is a protein-coding gene located on chromosome X.

CDK16 is a human gene that encodes a cyclin-dependent kinase involved in various cellular processes, including vesicle trafficking, neuronal function, and hormone regulation.

CDK16 is a protein kinase involved in vesicle-mediated transport and exocytosis, influencing processes like GH1 release in brain neurons, NSF oligomerization, spermatogenesis, neuronal differentiation, dendrite development, and insulin secretion regulation in response to blood glucose fluctuations. CDK16 can phosphorylate CCNY at Ser-336 in vitro.

CDK16 is also known as PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1.

Associated Diseases

• cancer
• male infertility with teratozoospermia due to single gene mutation
• partial chromosome Y deletion
• lung cancer
• spermatogenic failure 72
• spermatogenic failure 65
• spermatogenic failure 18
• spermatogenic failure 46
• spermatogenic failure 27
• spermatogenic failure 19
• spermatogenic failure 49
• spermatogenic failure 43
• spermatogenic failure 45
• spermatogenic failure 42
• spermatogenic failure, X-linked, 3