CDCP1
Description
The CDCP1 (CUB domain containing protein 1) is a protein-coding gene located on chromosome 3.
CDCP1 (CUB domain-containing protein 1) is a protein encoded by the CDCP1 gene in humans. It is also known as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). CDCP1 is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD). It is cleaved by serine proteases at the extracellular domain, generating a truncated 80 kDa molecule. The intracellular domain of CDCP1 contains five tyrosine residues that can be phosphorylated during cell detachment or mitosis. The phosphorylation of CDCP1 is observed in many cancers, including pre-invasive cancers, invasive tumors, and metastases.
CDCP1 may be involved in cell adhesion and cell matrix association. Its phosphorylation may play a role in regulating the balance between anchorage and migration, as well as proliferation and differentiation. CDCP1 could serve as a novel marker for leukemia diagnosis and for identifying immature hematopoietic stem cell subsets. It belongs to the tetraspanin web, which is implicated in tumor progression and metastasis.
CDCP1 is also known as CD318, SIMA135, TRASK.
