CDC27

Description

The CDC27 (cell division cycle 27) is a protein-coding gene located on chromosome 17.

CDC27 is a protein encoded by the CDC27 gene in humans. It shares similarities with proteins found in yeast and is a component of the anaphase-promoting complex (APC), a highly conserved complex in eukaryotic cells. APC is responsible for the degradation of cyclin B, a key protein involved in cell cycle regulation. CDC27 interacts with proteins involved in controlling the timing of mitosis, potentially playing a role in regulating cell division.

CDC27 is a component of the anaphase-promoting complex/cyclosome (APC/C), a key regulator of the cell cycle. APC/C is an E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle by targeting specific proteins for degradation. This process is mediated by the attachment of ubiquitin chains to target proteins, primarily through the formation of 'Lys-11'-linked polyubiquitin chains. APC/C also forms 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, but to a lesser extent.

CDC27 is also known as ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2.

Associated Diseases

• congenital anomaly of cardiovascular system
• congenital anomaly of the great arteries
• esophageal cancer
• cancer