CDC25C
Description
The CDC25C (cell division cycle 25C) is a protein-coding gene located on chromosome 5.
CDC25C, encoded by the CDC25C gene, is a highly conserved enzyme that plays a crucial role in cell division. It belongs to the Cdc25 phosphatase family and functions as a tyrosine phosphatase. CDC25C activates entry into mitosis by dephosphorylating cyclin B-bound CDC2 (CDK1). It is also believed to suppress p53-induced growth arrest. Multiple splice variants of this gene have been described, although the full-length nature of many remains unknown. CDC25C interacts with several proteins, including MAPK14, CHEK1, PCNA, PIN1, PLK3, and NEDD4.
CDC25C is a crucial regulator of cell division, acting as a dosage-dependent inducer in mitotic control. It functions as a tyrosine protein phosphatase, essential for the progression of the cell cycle. Phosphorylation of CDC25C significantly enhances its ability to activate G2 cells, pushing them into prophase. CDC25C directly dephosphorylates CDK1, leading to activation of its kinase activity.
CDC25C is also known as CDC25, PPP1R60.
Associated Diseases
- Alzheimer disease
- endometrial cancer
- esophageal cancer
- schizophrenia
- bipolar disorder
- glaucoma
- anorexia nervosa
