CDC25B
Description
The CDC25B (cell division cycle 25B) is a protein-coding gene located on chromosome 20.
CDC25B is a member of the CDC25 family of phosphatases, encoded by the CDC25B gene in humans. It plays a crucial role in cell division by activating the cyclin-dependent kinase CDC2. This activation occurs by removing two phosphate groups from CDC2, allowing the cell to enter mitosis. CDC25B moves between the nucleus and cytoplasm during the cell cycle, primarily residing in the nucleus during M and G1 phases and shifting to the cytoplasm during S and G2 phases. While CDC25B has been linked to oncogenic properties, its specific role in tumor formation remains unclear. Multiple transcript variants have been identified for this gene. CDC25B interacts with various proteins, including MAPK14, Casein kinase 2, alpha 1, CHEK1, MELK, Estrogen receptor alpha, YWHAB, YWHAZ, YWHAH, and YWHAE.
CDC25B is a tyrosine protein phosphatase that acts as a dosage-dependent inducer of mitotic progression. It directly dephosphorylates CDK1, stimulating its kinase activity. CDC25B is essential for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. The three isoforms of CDC25B appear to have varying levels of activity.
CDC25B is also known as -.
