CDC25A
Description
The CDC25A (cell division cycle 25A) is a protein-coding gene located on chromosome 3.
CDC25A is a protein encoded by the CDC25A gene in humans. It belongs to the CDC25 family of dual-specificity phosphatases, which remove phosphate groups from phosphorylated tyrosine and serine/threonine residues. CDC25A is essential for the transition from G1 to S phase of the cell cycle and plays a role in later cell cycle events. It is stabilized in metaphase cells and degraded upon metaphase exit. CDC25A activates the G1/S cyclin-dependent kinases CDK4 and CDK2 by removing inhibitory phosphate groups and can also activate Cdc2 (Cdk1), the primary mitotic Cdk. In response to DNA damage, CDC25A is specifically degraded, leading to cell cycle arrest. This degradation serves as part of a DNA damage checkpoint, alongside the induction of p53 and p21 in inhibiting CDKs.
CDC25A is a tyrosine protein phosphatase that acts as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:12676925, PubMed:14559997, PubMed:20360007). It directly dephosphorylates CDK1, stimulating its kinase activity (PubMed:20360007). CDC25A also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007).
CDC25A is also known as CDC25A2.
