CD84

Description

The CD84 (CD84 molecule) is a protein-coding gene located on chromosome 1.

CD84 (Cluster of Differentiation 84) is a human protein encoded by the CD84 gene. Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells. CD84 has been shown to interact with SH2D1A.

CD84, also known as SLAM family member 5, is a self-ligand receptor involved in immune cell activation and differentiation. It belongs to the signaling lymphocytic activation molecule (SLAM) family, whose members are triggered by cell-cell interactions. CD84's activity is regulated by the presence of small cytoplasmic adapter proteins, SH2D1A/SAP and SH2D1B/EAT-2. It mediates NK cell cytotoxicity, enhances T-cell proliferation, and promotes interferon gamma secretion in lymphocytes. CD84 also plays a role in platelet stimulation, hematopoietic progenitor cell identification, and T follicular helper function. Additionally, it is involved in maintaining B-cell tolerance, preventing autoimmunity, regulating mast cell signaling, modulating macrophage responses, and positively regulating macroautophagy in dendritic cells.

CD84 is also known as LY9B, SLAMF5, hCD84, mCD84.

Associated Diseases

WES Whole Exome Sequencing