CD40

Description

The CD40 gene encodes a transmembrane protein, CD40, that plays a crucial role in the immune system. It acts as a signaling receptor on antigen-presenting cells (APCs) like B cells, macrophages, and dendritic cells. When activated by its ligand, CD40L, it triggers a cascade of signaling events leading to the production of cytokines, antibody production, and the activation of other immune cells. This intricate interplay of CD40 and its ligand is essential for various immune responses, including B cell activation, T cell differentiation, and the control of inflammation. Dysregulation of the CD40 pathway is associated with a range of autoimmune disorders and malignancies, highlighting its significance in maintaining immune homeostasis.

Associated Diseases

• Systemic lupus erythematosus (SLE)
• Rheumatoid arthritis (RA)
• Multiple sclerosis (MS)
• Crohn‘s disease
• Inflammatory bowel disease (IBD)
• Cancer (e.g., B-cell lymphoma, breast cancer)

Did you know?

CD40 and its ligand (CD40L) have been implicated in the pathogenesis of graft-versus-host disease (GVHD), a serious complication following bone marrow transplantation.