CD300LF
Description
The CD300LF (CD300 molecule like family member f) is a protein-coding gene located on chromosome 17.
CD300LF, also known as CMRF35-like molecule 1, is a protein encoded by the CD300LF gene. It belongs to the CD300 protein family and is a membrane glycoprotein expressed by myeloid and mast cells. CD300LF plays a role in immunoregulation and may be involved in norovirus infections. It acts as the primary receptor for murine norovirus in mice, but human norovirus does not use the same receptor for entry. While human and murine CD300LF proteins share similarities, differences in their structures contribute to the host species restriction of murine norovirus.
CD300LF acts as an inhibitory receptor on myeloid cells and mast cells, regulating their activation. It promotes the phagocytosis of apoptotic cells by recognizing phosphatidylserine on their surface, contributing to immune homeostasis. CD300LF also inhibits mast cell activation and allergic responses by binding to ceramide and sphingomyelin. It may function as a coreceptor for interleukin 4 (IL-4), regulating IL-4 receptor alpha-mediated responses. Additionally, CD300LF negatively regulates Toll-like receptor signaling, inhibits osteoclast formation, and induces macrophage cell death upon engagement.
CD300LF is also known as CD300f, CLM-1, CLM1, IREM-1, IREM1, IgSF13, LMIR3, NKIR.
