CD209

Description

The CD209 (CD209 molecule) is a protein-coding gene located on chromosome 19.

DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene. DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds with high affinity to high-mannose type N-glycans, a class of PAMPs (pathogen associated molecular patterns) commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis. On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens.

== Function == DC-SIGN is a C-type lectin and has a high affinity for the ICAM3 molecule. It binds various microorganisms by recognizing high-mannose-containing glycoproteins on their surface, and can function as a co-receptor for several viruses such as HIV and Hepatitis C. Binding to DC-SIGN can promote HIV and Hepatitis C virus to infect target cells (T-cells and hepatocytes, respectively). Besides functioning as an adhesion molecule, recent studies have also shown that DC-SIGN can initiate innate immunity by modulating toll-like receptors, though the detailed mechanism is not yet known. DC-SIGN together with other C-type lectins is involved in recognition of tumors by dendritic cells. DC-SIGN is also a potential engineering target for dendritic cell based cancer vaccine.

CD209, also known as DC-SIGN, is a pathogen recognition receptor found on immature dendritic cells (DCs). It plays a crucial role in initiating the primary immune response. DC-SIGN mediates the internalization of pathogens through endocytosis, followed by degradation within lysosomal compartments. The receptor then returns to the cell membrane surface, presenting pathogen-derived antigens to resting T-cells via MHC class II proteins. This antigen presentation initiates the adaptive immune response.

CD209 is also known as CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, hDC-SIGN.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing