CD200R1
Description
The CD200R1 (CD200 receptor 1) is a protein-coding gene located on chromosome 3.
CD200 receptor 1 (CD200R1) is a protein that is found on the surface of certain immune cells, such as myeloid cells and CD4+ T cells. It is encoded by the CD200R1 gene in humans. CD200R1 interacts with the CD200 protein, which is found on various cell types, including neurons, epithelial cells, endothelial cells, fibroblasts, and lymphoid cells. When CD200R1 is activated, it regulates the production of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha), interferons, and inducible nitric oxide synthase (iNOS). CD200R1 is thought to play a role in controlling immune responses, possibly by dampening inflammation. Alternative splicing of the CD200R1 gene results in several different versions of the protein.
CD200R1 is an inhibitory receptor for the CD200/OX2 cell surface glycoprotein. It acts as an anti-inflammatory agent by blocking the production of pro-inflammatory molecules like TNF-alpha, interferons, and iNOS in response to certain stimuli. Additionally, it binds to the HHV-8 K14 viral CD200 homolog with the same strength and speed as it binds to the host CD200.
CD200R1 is also known as CD200R, HCRTR2, MOX2R, OX2R.
