CD200
Description
The CD200 (CD200 molecule) is a protein-coding gene located on chromosome 3.
CD200 (Cluster of Differentiation 200) is a human protein encoded by the CD200 gene, located on chromosome 3. It's a type-1 membrane glycoprotein belonging to the immunoglobulin superfamily, particularly the B7 receptor family. It has two IgSF immunoglobulin domains, a transmembrane region, and a 19-amino-acid cytoplasmic domain. CD200 is expressed on various cell types, including dendritic cells, activated B and T lymphocytes, thymocytes, endothelial cells, neurons, osteoblast precursors, and various cancer cells. Its expression is induced by TLRs, NLRs, IFN-γ, and TNF-α in a NF-kappaB, STAT1, and IRF-1-dependent manner. A soluble form of CD200 (sCD200) is also present in serum.
CD200 is also known as MOX1, MOX2, MRC, OX-2.
