CD177
Description
The CD177 (CD177 molecule) is a protein-coding gene located on chromosome 19.
CD177 antigen is a protein encoded by the CD177 gene in humans. It is a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein first identified in a case of neonatal alloimmune neutropenia. CD177 is involved in various aspects of neutrophil function, including activation, adhesion, migration, and interaction with other cells and molecules.
CD177, when associated with the beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, triggers the activation of TNF-alpha primed neutrophils, leading to degranulation and superoxide production. It also promotes adhesion over migration by inhibiting beta-2 integrin internalization and suppressing chemokine signaling. CD177 interacts with PECAM1 on endothelial cells, contributing to neutrophil transendothelial migration in vitro. However, it seems to be nonessential for neutrophil recruitment during bacterial infection in vivo. CD177 acts as a receptor for mature PRTN3 protease, enabling its presentation on the neutrophil surface. This display of PRTN3 may contribute to enhancing endothelial cell junctional integrity and vascular integrity during neutrophil diapedesis.
CD177 is also known as HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1.
Associated Diseases
- cancer
- breast cancer
- X-linked severe congenital neutropenia
- neutrophil immunodeficiency syndrome
- nonimmune chronic idiopathic neutropenia of adults
- neutropenia, severe congenital, 2, autosomal dominant
- myeloperoxidase deficiency
- neutropenia-monocytopenia-deafness syndrome
